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Clinically, Wangbi Capsule (WBC) is widely used in the treatment of Rheumatoid arthritis (RA) because of its remarkable therapeutic effect. To reveal the mechanism, a pharmacokinetic–pharmacodynamic (PK–PD) model was developed for the first time to assess the relationship between time–concentration (dose)–effect. Freund’s Complete Adjuvant was used to induce the adjuvant‐induced arthritis model. Multi‐indices...